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Agilent 6520 Q-TOF LC/MS System

Brief Description:The Agilent 6520 Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS System is a high-resolution mass spectrometry platform designed for accurate mass measurement, compound identification, and advanced structural analysis. It combines a quadrupole mass

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Detailed Introduction

Agilent 6520 Q-TOF LC/MS System Introduction

The Agilent 6520 Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS System is a high-resolution mass spectrometry platform designed for accurate mass measurement, compound identification, and advanced structural analysis. It combines a quadrupole mass filter with a high-performance time-of-flight (TOF) analyzer, providing excellent mass accuracy, high resolution, fast acquisition speed, and reliable analytical performance for complex samples.

The Agilent 6520 Q-TOF LC/MS is equipped with Agilent Jet Stream Electrospray Ionization (AJS ESI) technology, which enhances ion transmission efficiency and improves sensitivity for low-abundance compounds. The system supports both positive and negative ion modes and enables comprehensive MS and MS/MS analysis for small molecules, metabolites, peptides, proteins, and other biomolecules.

The quadrupole section allows selective precursor ion isolation, while the TOF analyzer provides accurate mass detection and high-resolution full-spectrum acquisition. This combination enables researchers to identify unknown compounds, determine molecular formulas, characterize metabolites, and perform detailed structural elucidation. The instrument is widely used in pharmaceutical discovery, metabolomics, proteomics, environmental analysis, food safety, and biotechnology research.

Controlled by Agilent MassHunter Workstation Software, the 6520 Q-TOF provides powerful tools for data acquisition, accurate mass analysis, molecular formula generation, database searching, and reporting. Its robust design and flexible configuration make it a valuable platform for laboratories requiring high-resolution LC/MS capabilities.

Agilent 6520 Q-TOF LC/MS System Specifications

Parameter Specification
Instrument Type Accurate-Mass Quadrupole Time-of-Flight LC/MS
Manufacturer Agilent Technologies
Model Agilent 6520 Q-TOF LC/MS
Mass Analyzer Quadrupole + Time-of-Flight (Q-TOF)
Mass Range m/z 50–3200
Mass Resolution Up to approximately 20,000 FWHM
Mass Accuracy Typically ≤2–5 ppm with calibration
Ion Source Agilent Jet Stream Electrospray Ionization (AJS ESI)
Ion Modes Positive and Negative Ion Modes
MS/MS Capability Precursor ion selection and collision-induced dissociation
Acquisition Speed High-speed full spectrum acquisition
Software Agilent MassHunter Workstation Software
LC Compatibility Agilent 1100 / 1200 / 1260 / 1290 LC Systems
Applications Proteomics, metabolomics, pharmaceutical research, environmental analysis
Sample Types Small molecules, peptides, proteins, metabolites
Detector Type High-resolution TOF detector
Key Advantages Accurate mass, high resolution, fast acquisition, structural identification

The Agilent 6520 Q-TOF LC/MS System is a proven high-resolution analytical platform that provides powerful identification and characterization capabilities. Its combination of accuracy, sensitivity, and versatility makes it an excellent choice for research laboratories requiring advanced LC-MS analysis.

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