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Detailed Introduction
The Agilent 6520 Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) LC/MS System is a high-resolution mass spectrometry platform designed for accurate mass measurement, compound identification, and advanced structural analysis. It combines a quadrupole mass filter with a high-performance time-of-flight (TOF) analyzer, providing excellent mass accuracy, high resolution, fast acquisition speed, and reliable analytical performance for complex samples.
The Agilent 6520 Q-TOF LC/MS is equipped with Agilent Jet Stream Electrospray Ionization (AJS ESI) technology, which enhances ion transmission efficiency and improves sensitivity for low-abundance compounds. The system supports both positive and negative ion modes and enables comprehensive MS and MS/MS analysis for small molecules, metabolites, peptides, proteins, and other biomolecules.
The quadrupole section allows selective precursor ion isolation, while the TOF analyzer provides accurate mass detection and high-resolution full-spectrum acquisition. This combination enables researchers to identify unknown compounds, determine molecular formulas, characterize metabolites, and perform detailed structural elucidation. The instrument is widely used in pharmaceutical discovery, metabolomics, proteomics, environmental analysis, food safety, and biotechnology research.
Controlled by Agilent MassHunter Workstation Software, the 6520 Q-TOF provides powerful tools for data acquisition, accurate mass analysis, molecular formula generation, database searching, and reporting. Its robust design and flexible configuration make it a valuable platform for laboratories requiring high-resolution LC/MS capabilities.
| Parameter | Specification |
|---|---|
| Instrument Type | Accurate-Mass Quadrupole Time-of-Flight LC/MS |
| Manufacturer | Agilent Technologies |
| Model | Agilent 6520 Q-TOF LC/MS |
| Mass Analyzer | Quadrupole + Time-of-Flight (Q-TOF) |
| Mass Range | m/z 50–3200 |
| Mass Resolution | Up to approximately 20,000 FWHM |
| Mass Accuracy | Typically ≤2–5 ppm with calibration |
| Ion Source | Agilent Jet Stream Electrospray Ionization (AJS ESI) |
| Ion Modes | Positive and Negative Ion Modes |
| MS/MS Capability | Precursor ion selection and collision-induced dissociation |
| Acquisition Speed | High-speed full spectrum acquisition |
| Software | Agilent MassHunter Workstation Software |
| LC Compatibility | Agilent 1100 / 1200 / 1260 / 1290 LC Systems |
| Applications | Proteomics, metabolomics, pharmaceutical research, environmental analysis |
| Sample Types | Small molecules, peptides, proteins, metabolites |
| Detector Type | High-resolution TOF detector |
| Key Advantages | Accurate mass, high resolution, fast acquisition, structural identification |
The Agilent 6520 Q-TOF LC/MS System is a proven high-resolution analytical platform that provides powerful identification and characterization capabilities. Its combination of accuracy, sensitivity, and versatility makes it an excellent choice for research laboratories requiring advanced LC-MS analysis.
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