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Detailed Introduction
The Agilent 6420 Triple Quadrupole LC/MS System is a highly sensitive tandem mass spectrometry platform designed for accurate quantitative analysis of complex samples. It combines Agilent’s reliable triple quadrupole mass analyzer technology with advanced LC/MS capabilities, providing excellent sensitivity, selectivity, and reproducibility for applications in pharmaceutical research, clinical analysis, environmental monitoring, food safety, and biotechnology.
The Agilent 6420 Triple Quad LC/MS uses a triple quadrupole (QqQ) configuration that enables highly specific Multiple Reaction Monitoring (MRM) analysis. The first quadrupole selects the precursor ion, the second quadrupole acts as a collision cell for fragmentation, and the third quadrupole monitors the product ion. This design provides outstanding compound identification and quantification performance, even in complex sample matrices.
Featuring Agilent’s advanced Electrospray Ionization (ESI) technology, the 6420 delivers efficient ion generation and excellent detection capability for low-concentration compounds. It supports positive and negative ion modes and is suitable for the analysis of pharmaceuticals, metabolites, pesticides, hormones, and other trace-level compounds.
The system is operated through Agilent MassHunter software, offering intuitive control, method optimization, quantitative analysis, and reporting functions. Its robust construction and dependable performance make the Agilent 6420 Triple Quad LC/MS an excellent choice for laboratories requiring reliable LC-MS/MS workflows.
| Parameter | Specification |
|---|---|
| Instrument Type | Triple Quadrupole Liquid Chromatography Tandem Mass Spectrometer |
| Manufacturer | Agilent Technologies |
| Model | Agilent 6420 Triple Quad LC/MS |
| Mass Analyzer | Triple Quadrupole (QqQ) |
| Mass Range | m/z 5–2000 |
| MS/MS Technology | Tandem Mass Spectrometry |
| Quantitation Mode | Multiple Reaction Monitoring (MRM) |
| Ion Source | Electrospray Ionization (ESI) |
| Ion Modes | Positive and Negative Ion Modes |
| Collision Cell | High-performance collision cell |
| Sensitivity | High sensitivity for trace compound detection |
| LC Compatibility | Agilent 1200 / 1260 Infinity LC Systems |
| Software | Agilent MassHunter Workstation Software |
| Acquisition Modes | MRM, Product Ion Scan, Precursor Ion Scan |
| Applications | Pharmaceutical analysis, clinical testing, food safety, environmental analysis |
| Sample Types | Drugs, metabolites, pesticides, biological samples |
| Detector Type | Triple Quadrupole Mass Detector |
| Key Features | High selectivity, excellent quantitative accuracy, reliable operation |
The Agilent 6420 Triple Quadrupole LC/MS System provides a cost-effective and dependable solution for laboratories requiring high-performance LC-MS/MS analysis. Its combination of sensitivity, robustness, and ease of operation makes it widely used for routine quantitative testing and advanced analytical research.
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