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Detailed Introduction
The Agilent 6460 Triple Quadrupole LC/MS System is an advanced tandem mass spectrometry platform designed for ultra-sensitive quantitative analysis and complex sample characterization. It combines Agilent’s innovative triple quadrupole technology with Jet Stream Electrospray Ionization (AJS ESI) to deliver exceptional sensitivity, accuracy, and reproducibility for demanding applications in pharmaceutical, clinical, environmental, food safety, and biotechnology laboratories.
The Agilent 6460 Triple Quad LC/MS features a high-performance QqQ mass analyzer with advanced collision cell technology, enabling highly selective Multiple Reaction Monitoring (MRM) analysis. This allows researchers to accurately quantify trace-level compounds in complex matrices, including drugs, metabolites, biomarkers, pesticides, and environmental contaminants.
With Agilent Jet Stream technology, the 6460 improves ion transmission efficiency and enhances detection performance compared with conventional ESI sources. The system supports positive and negative ionization modes and provides reliable quantitative results with excellent sensitivity and dynamic range. It is widely used in regulated environments requiring high analytical precision and repeatability.
The instrument is controlled by Agilent MassHunter Workstation Software, which provides powerful tools for method development, quantitative analysis, data processing, and reporting. The Agilent 6460 is compatible with Agilent Infinity LC systems, creating an integrated LC-MS/MS workflow.
Known for its sensitivity, robustness, and operational efficiency, the Agilent 6460 Triple Quadrupole LC/MS System is an ideal choice for laboratories requiring high-performance quantitative mass spectrometry solutions.
| Parameter | Specification |
|---|---|
| Instrument Type | Triple Quadrupole Liquid Chromatography Tandem Mass Spectrometer |
| Manufacturer | Agilent Technologies |
| Model | Agilent 6460 Triple Quad LC/MS |
| Mass Analyzer | Triple Quadrupole (QqQ) |
| Mass Range | m/z 5–2000 |
| Ion Source | Agilent Jet Stream Electrospray Ionization (AJS ESI) |
| Ion Modes | Positive and Negative Ion Modes |
| Quantitation Mode | Multiple Reaction Monitoring (MRM) |
| Collision Cell | High-performance hexapole collision cell |
| Sensitivity | Ultra-high sensitivity for trace-level analysis |
| Dynamic Range | Wide quantitative dynamic range |
| LC Compatibility | Agilent 1200 / 1260 / 1290 Infinity LC Systems |
| Software | Agilent MassHunter Workstation Software |
| Acquisition Modes | MRM, Product Ion Scan, Precursor Ion Scan |
| Applications | Pharmaceutical, clinical, environmental, food, biotechnology analysis |
| Sample Types | Small molecules, metabolites, proteins, biological samples |
| Detector Type | Triple Quadrupole Mass Detector |
| Key Advantages | High sensitivity, excellent selectivity, reliable quantitation |
The Agilent 6460 Triple Quadrupole LC/MS System delivers outstanding analytical performance for laboratories that require precise, sensitive, and reproducible LC-MS/MS measurements, making it one of Agilent’s widely adopted platforms for advanced quantitative analysis.
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