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Agilent 6460 Triple Quad LC/MS System

Brief Description:The Agilent 6460 Triple Quadrupole LC/MS System is an advanced tandem mass spectrometry platform designed for ultra-sensitive quantitative analysis and complex sample characterization.

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Detailed Introduction

Agilent 6460 Triple Quadrupole LC/MS System Introduction

The Agilent 6460 Triple Quadrupole LC/MS System is an advanced tandem mass spectrometry platform designed for ultra-sensitive quantitative analysis and complex sample characterization. It combines Agilent’s innovative triple quadrupole technology with Jet Stream Electrospray Ionization (AJS ESI) to deliver exceptional sensitivity, accuracy, and reproducibility for demanding applications in pharmaceutical, clinical, environmental, food safety, and biotechnology laboratories.

The Agilent 6460 Triple Quad LC/MS features a high-performance QqQ mass analyzer with advanced collision cell technology, enabling highly selective Multiple Reaction Monitoring (MRM) analysis. This allows researchers to accurately quantify trace-level compounds in complex matrices, including drugs, metabolites, biomarkers, pesticides, and environmental contaminants.

With Agilent Jet Stream technology, the 6460 improves ion transmission efficiency and enhances detection performance compared with conventional ESI sources. The system supports positive and negative ionization modes and provides reliable quantitative results with excellent sensitivity and dynamic range. It is widely used in regulated environments requiring high analytical precision and repeatability.

The instrument is controlled by Agilent MassHunter Workstation Software, which provides powerful tools for method development, quantitative analysis, data processing, and reporting. The Agilent 6460 is compatible with Agilent Infinity LC systems, creating an integrated LC-MS/MS workflow.

Known for its sensitivity, robustness, and operational efficiency, the Agilent 6460 Triple Quadrupole LC/MS System is an ideal choice for laboratories requiring high-performance quantitative mass spectrometry solutions.

Agilent 6460 Triple Quadrupole LC/MS System Specifications

Parameter Specification
Instrument Type Triple Quadrupole Liquid Chromatography Tandem Mass Spectrometer
Manufacturer Agilent Technologies
Model Agilent 6460 Triple Quad LC/MS
Mass Analyzer Triple Quadrupole (QqQ)
Mass Range m/z 5–2000
Ion Source Agilent Jet Stream Electrospray Ionization (AJS ESI)
Ion Modes Positive and Negative Ion Modes
Quantitation Mode Multiple Reaction Monitoring (MRM)
Collision Cell High-performance hexapole collision cell
Sensitivity Ultra-high sensitivity for trace-level analysis
Dynamic Range Wide quantitative dynamic range
LC Compatibility Agilent 1200 / 1260 / 1290 Infinity LC Systems
Software Agilent MassHunter Workstation Software
Acquisition Modes MRM, Product Ion Scan, Precursor Ion Scan
Applications Pharmaceutical, clinical, environmental, food, biotechnology analysis
Sample Types Small molecules, metabolites, proteins, biological samples
Detector Type Triple Quadrupole Mass Detector
Key Advantages High sensitivity, excellent selectivity, reliable quantitation

The Agilent 6460 Triple Quadrupole LC/MS System delivers outstanding analytical performance for laboratories that require precise, sensitive, and reproducible LC-MS/MS measurements, making it one of Agilent’s widely adopted platforms for advanced quantitative analysis.

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