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Detailed Introduction
The Agilent 6490 Triple Quadrupole LC/MS System is a high-end tandem mass spectrometry platform designed for ultra-sensitive quantitative analysis of complex samples. It represents one of Agilent’s most powerful triple quadrupole LC/MS instruments, combining advanced iFunnel Technology, Jet Stream Electrospray Ionization (AJS ESI), and high-performance QqQ mass analysis to achieve exceptional sensitivity, selectivity, and reproducibility.
The Agilent 6490 Triple Quad LC/MS features a triple quadrupole configuration optimized for Multiple Reaction Monitoring (MRM) workflows. The first quadrupole isolates precursor ions, the second quadrupole provides collision-induced fragmentation, and the third quadrupole monitors specific product ions. This highly selective process enables accurate detection and quantification of trace-level compounds in challenging matrices.
With enhanced ion transmission efficiency and improved signal stability, the 6490 provides outstanding performance for applications requiring extremely low detection limits, including clinical research, pharmaceutical bioanalysis, biomarker discovery, environmental analysis, food safety testing, and forensic applications. The system is particularly suitable for analyzing low-abundance compounds in biological samples such as plasma, serum, and tissue extracts.
The instrument is operated through Agilent MassHunter Workstation Software, which supports advanced method development, quantitative analysis, data processing, and reporting. Combined with Agilent Infinity LC systems, the 6490 delivers a complete and reliable LC-MS/MS solution for modern analytical laboratories.
The Agilent 6490 Triple Quad LC/MS System is widely recognized for its industry-leading sensitivity, robustness, and quantitative accuracy, making it an excellent choice for laboratories requiring the highest level of LC-MS/MS performance.
| Parameter | Specification |
|---|---|
| Instrument Type | Triple Quadrupole Liquid Chromatography Tandem Mass Spectrometer |
| Manufacturer | Agilent Technologies |
| Model | Agilent 6490 Triple Quad LC/MS |
| Mass Analyzer | Triple Quadrupole (QqQ) |
| Mass Range | m/z 5–2000 |
| Ion Source | Agilent Jet Stream Electrospray Ionization (AJS ESI) |
| Ionization Modes | Positive and Negative Ion Modes |
| Sensitivity Technology | iFunnel Technology |
| Quantitation Mode | Multiple Reaction Monitoring (MRM) |
| Collision Cell | High-efficiency collision cell |
| Detection Capability | Ultra-trace level quantitative analysis |
| Dynamic Range | Wide quantitative dynamic range |
| LC Compatibility | Agilent 1200 / 1260 / 1290 Infinity LC Systems |
| Software | Agilent MassHunter Workstation Software |
| Acquisition Modes | MRM, Product Ion Scan, Precursor Ion Scan |
| Applications | Clinical research, pharmaceutical analysis, environmental testing, food safety |
| Sample Types | Plasma, serum, metabolites, drugs, biomarkers |
| Detector Type | Triple Quadrupole Mass Detector |
| Key Advantages | Maximum sensitivity, high selectivity, excellent reproducibility |
The Agilent 6490 Triple Quad LC/MS System provides exceptional analytical capability for laboratories performing demanding quantitative workflows. Its combination of ultra-high sensitivity, advanced ion technology, and reliable operation makes it a leading platform for advanced LC-MS/MS applications.
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